How is Allergic Vasculitis Diagnosed?

How is allergic vasculitis diagnosed?

Allergic vasculitis is a vascular inflammatory disease characterized by small blood vessels, veins and capillaries, also known as vasculitis, allergic vasculitis and leukocytic fragmentation vasculitis. Allergic vasculitis is a disease that seriously affects the life of patients.

1. TCM Diagnosis of Allergic Vasculitis

1. The rash caused by Yin deficiency and blood heat appears repeatedly, leaving more pigmentation or atrophic scars on the skin, dry mouth, irritability, insomnia, frequent dreams, dry stool, red tongue with little coating, and thin pulse.

2. Cold-dampness rashes are purpuric papules and macular papules. The color of skin lesions is mostly normal or dark red, with mild pain, thirst, loose stools, pale tongue, white or greasy tongue coating, and heavy and slow pulse.

3. The rash caused by damp-heat blocking the collaterals is mainly distributed on the lower limbs, with purpuric papules as the basis, accompanied by blood blisters, ulcers, fever, swollen and painful joints, loose stools, short and red urine, red tongue, yellow and greasy tongue coating, and infiltrated or greasy pulse.

2. Western medicine diagnosis of allergic vasculitis

1. Laboratory examinations showed no obvious abnormalities, with eosinophilia in a few cases. In severe cases, anemia, rapid increase in erythrocyte sedimentation rate, decrease in serum complement and C3, and renal involvement, including proteinuria, hematuria, and renal tubular type, were observed.

2. Histopathology: dilation of posterior capillaries, swelling of endothelial cells, stenosis of lumen, thrombosis, fibrinoid degeneration, neutrophil infiltration, nuclear dust inflammatory cell infiltration, and red blood cell overflow in the dermis. Immunopathology shows that the fibrin deposition around the veins is mainly IgG, and IgM and IgA can sometimes be detected.

3. Clinical manifestations: The typical manifestation of skin damage is hemorrhagic maculopapular rash, which does not subside after pressing. Others include papules, wheals, blood blisters, nodules, ulcers, necrosis and other injuries. Mild patients have slight itching, tingling or burning pain locally, and severe patients may have systemic symptoms such as fever, headache, and joint pain.