What are the consequences of high IgG4?

Increased IgG4 may lead to serious consequences such as autoimmune diseases, chronic inflammation or tumors, and timely medical treatment and targeted treatment are required. Increased IgG4 may be related to genetic, environmental, physiological, traumatic or pathological factors, and the specific cause needs to be clarified through blood tests, imaging examinations and other means.

1. Autoimmune diseases: Elevated IgG4 is closely related to autoimmune diseases, such as IgG4-related disease IgG4-RD, which can affect multiple organs, such as the pancreas, bile duct, salivary glands, etc. Treatment includes the use of glucocorticoids such as prednisone, immunosuppressants such as cyclophosphamide, and biological agents such as rituximab. Early diagnosis and treatment can help control the progression of the disease.

2. Chronic inflammation: Increased IgG4 may indicate the presence of chronic inflammation, such as chronic pancreatitis, cholangitis, etc. Long-term chronic inflammation may lead to impaired organ function. Treatment should be targeted at the primary disease, such as the use of anti-inflammatory drugs such as ibuprofen, antibiotics such as amoxicillin, and nutritional support. Regular review and adjustment of treatment plans are key.

3. Tumors: Increased IgG4 may be associated with certain tumors, such as pancreatic cancer, bile duct cancer, etc. Early detection and timely treatment of tumors are crucial. Treatments include surgical resection, chemotherapy such as gemcitabine, and radiotherapy. Comprehensive treatment can improve survival rate and quality of life.

Increased IgG4 may indicate a variety of serious diseases, which require professional examinations and treatment to identify the cause and take appropriate measures. Regular physical examinations and early intervention are effective means to prevent and control related diseases.