What is the cause of allergic vasculitis

What is the cause of allergic vasculitis?

Allergic vasculitis is a type of vasculitis, also known as hypersensitivity vasculitis, formerly known as cutaneous leukocytoclastic vasculitis. The disease is acute or chronic, and patients will have typical skin symptoms, manifested as bright red purpura, which gradually evolves into polymorphic skin lesions such as blisters, pustules, nodules, etc., and even necrosis or ulcers.

1. Infection. The cause of allergic vasculitis is very complicated. It usually occurs after the allergic constitution is stimulated by allergens and is related to pathogen infection. There are many kinds of pathogens that can cause diseases, including bacteria, viruses, fungi and protozoa, including streptococci, tuberculosis, influenza virus, Candida, etc. Some patients will have prodromal symptoms before the onset of the disease, such as fever, muscle aches, joint pain, mental fatigue, etc.

2. Drugs. Many drugs can induce allergic vasculitis, such as penicillin, aspirin, sulfonamides, Pronesen and methotrexate. Heterogeneous protein serum is also an important cause of the disease. Before using these drugs, patients must undergo drug sensitivity tests. During the medication process, if discomfort occurs, the drug should be stopped in time.

3. Immune abnormalities. Allergic vasculitis is related to immune abnormalities. If the patient suffers from hypergammaglobulinemia, the risk of developing this disease will be greatly increased.

4. Other causes. Other causes of allergic vasculitis include long-term smoking, stimulation by radioactive substances, etc. These factors can damage the blood vessel wall or induce vascular wall inflammation through immune mediation, thus leading to vasculitis.

The above are the causes of allergic vasculitis, including infection, drugs, immune abnormalities and other inducers. In some cases, the cause cannot be determined, and symptomatic treatment is the main treatment in clinical practice. This disease is more acute, and glucocorticoids can be used to control the condition, commonly used ones are prednisone, methylprednisone, etc. If the condition is mild, with only minor skin damage and no involvement of internal organs, antihistamines can be used for treatment. If combined with infection, antibiotic treatment is necessary.