What is Anka's Vasculitis?

Anka's vasculitis is an autoimmune disease that manifests itself as inflammation of small blood vessels. In severe cases, it can affect multiple organs and systems, including the respiratory tract and kidneys, which may pose a serious threat to health. The causes of the disease involve genetic factors, environmental stimulation, and immune system abnormalities. Treatment requires the selection of drugs to control inflammation based on specific circumstances, and regular follow-up.

1. Genetic factors

Genetics may play a role in the development of Anka's vasculitis. Patients with similar autoimmune diseases in their families are more likely to develop the disease. This may be related to the presence of certain gene mutations or susceptibility genes. Although it is impossible to clearly prevent genetic risks, high-risk groups should pay attention to regular physical examinations to detect abnormal changes early.

2. Influence of external environmental factors

Environmental stimuli such as viral or bacterial infection, smoking, and exposure to chemicals may induce abnormal responses of the immune system, leading to inflammation of small blood vessels. Especially after long-term exposure to irritating and harmful substances, it is more likely to cause immune system disorders. It is recommended to pay attention to the cleanliness of the living environment, reduce exposure to air pollutants, quit smoking, and maintain appropriate respiratory protection measures.

3. Abnormal autoimmune system

The core of Anka's vasculitis is the abnormal recognition ability of the immune system, which mistakenly attacks its own blood vessels. Studies have found that compared with the normal population, the level of anti-neutrophil cytoplasmic antibodies (ANCA) in the serum of patients is significantly increased. Treatment requires immunosuppressive drugs such as prednisone, cyclophosphamide or methotrexate to reduce the inflammatory response.

4. Possible pathological manifestations

Anka's vasculitis may manifest clinically as sinus problems, dyspnea, hematuria, joint pain, etc. These symptoms are related to the destruction of local tissues by vascular inflammation. If the above abnormal symptoms are found, you should see a doctor as soon as possible and confirm the diagnosis through blood tests, urine tests and imaging tests.

5. Treatment

Treatment mainly consists of medication control and long-term management.

Immunosuppressive therapy, such as the glucocorticoid prednisone combined with cyclophosphamide, can help slow disease activity.

Biological agents: In recent years, rituximab has been used to treat relapsed or refractory disease.

Blood purification therapy: If renal function is severely impaired, hemodialysis or plasma exchange may be selected.

Anka's vasculitis is a chronic disease that requires long-term management. Patients need to closely cooperate with doctors to follow up regularly and reduce the risk of recurrence by improving their lifestyle. For example, they should pay attention to dietary nutrition, eat more foods rich in antioxidants, and exercise appropriately to improve their body's immunity. The complexity of the disease determines that a multidisciplinary joint diagnosis and treatment model should be adopted when necessary.