Laboratory tests for ankle fasciitis

What are the tests for ankle fasciitis?

1. Eosinophilia is present in approximately 47.6% of cases.

2. About half of the patients had a faster increase in ESR.

If there is a concurrent hematological disorder, corresponding blood cell and bone marrow abnormalities may be seen, with occasional proteinuria.

3. Blood biochemistry and immunology examinations showed that ANA was 30.8% positive, anti-dsDNA antibody was 33.3% positive, RF was 36.4% positive, γ-globulin was 73.3% increased, IgG, IgA, and IgM were 60%, 26.7%, and 20% increased respectively, and CIC was 85.7% positive.

Histopathology:

At present, the diagnosis of EF mainly relies on histopathological examination. The biopsy material should reach the depth of the muscle and fascia. EF lesions are mainly in the fascia, showing collagen fiber proliferation, thickening and fibrosis, collagen transparency, glass changes or homogenization, perivascular infiltration of furnace lymphocytes, tissue cells and plasma cells, infiltration of different numbers of eosinophils, and vascular dilation and hyperplasia. The proliferating collagen tissue in the fascia can extend to the interval between the subcutaneous fat leaves and wrap part of the fat leaves in sclerotic lesions. It also affects the underlying muscles, causing inflammatory changes in the superficial muscles, with lymphocytes, plasma cells and eosinophils infiltrating around the interfascicular blood vessels. A few cases of dermis may also have the above-mentioned mild lesions; the epidermis is normal, and a few may have mild atrophy and increased basal pigment cells.

Skin direct immunofluorescence examination shows IgG and C3 in the fascia and intermuscular septa. IgG and C3 are deposited in the blood vessels deep in the dermis and around the subcutaneous fat, and IgM is deposited at the junction of the dermis and epidermis. However, these changes are nonspecific and not very helpful for the diagnosis of EF.