What is the cause of bilateral hydronephrosis and high creatinine

The main reasons for the increase in creatinine in bilateral hydronephrosis include impaired renal function caused by urinary tract obstruction, kidney inflammation or organic lesions caused by infection, and limited glomerular filtration function caused by long-term pressure damage. In such cases, the cause should be identified in time and treated in combination with the cause, such as relieving obstruction, controlling infection and protecting renal function.

1. Urinary tract obstruction leading to renal impairment

Urinary tract obstruction is one of the main causes of bilateral hydronephrosis, such as renal ureteral stones, urinary tract stenosis or prostatic hyperplasia. Obstruction can lead to obstruction of urine excretion, causing bilateral hydronephrosis, and long-term increase in intrarenal pressure damages kidney function and causes increased creatinine.

Solution:

-Drug treatment: such as alpha-receptor blockers (such as tamsulosin), which can temporarily relieve urinary tract obstruction.

-Minimally invasive surgery: Ureteroscopic lithotripsy and percutaneous nephrolithotomy are suitable for obstruction caused by stones.

-Drainage surgery: In severe bilateral hydronephrosis, a double J tube or nephrostomy tube is placed to relieve pressure.

2. Infection leading to kidney inflammation

If urine is retained in the kidneys for a long time, it is easy to cause infection, such as pyelonephritis. The invasion of bacteria can lead to inflammatory damage and lesions of the renal parenchyma. Coupled with the presence of bilateral hydronephrosis, the kidneys cannot perform their metabolic functions normally, leading to increased creatinine levels.

Solution:

- Antibiotic treatment: Choose appropriate antibiotics based on drug sensitivity testing, such as quinolones (such as levofloxacin) or cephalosporins.

-Regular follow-up: Urine culture and creatinine levels should be monitored regularly after treatment to ensure that the infection is under control.

-Water management: Drink more water to speed up urine excretion and reduce the burden on the kidneys.

3. Weakened glomerular filtration function

Long-term bilateral hydronephrosis can cause direct damage to the structure of renal tissue and glomeruli, which manifests as a decrease in the filtration function of the kidneys, resulting in the inability to excrete metabolic waste products such as creatinine normally and eventually accumulating in the body.

Solution:

- Renal function protection drugs: Use angiotensin-converting enzyme inhibitors (ACEI, such as benazepril) or angiotensin II receptor blockers (ARB, such as valsartan) to slow down the deterioration of renal function.

-Low-salt, low-protein diet: Dietary management helps reduce the burden on the kidneys and reduce the production of creatinine.

- Close follow-up: Regularly check indicators such as creatinine and urea nitrogen to promptly detect and treat deterioration of renal function.

Emphasis on medical treatment and prevention

Bilateral hydronephrosis and increased creatinine often indicate impaired renal function. This situation needs to be taken seriously. See a doctor as soon as possible to identify the cause and receive timely treatment to protect renal function. Pay attention to maintaining healthy drinking habits and prevent urinary tract infections. If you have symptoms such as difficulty urinating and discomfort in the waist and abdomen, you should seek medical help immediately.