What are the most likely causes of osteoporosis?

What are the most likely causes of osteoporosis?

There are many causes of osteoporosis, which are not yet fully understood. It may be the result of a combination of factors, or it may be just one of the causes, including genetics, endocrine, nutrition, disuse, age and immunity.

1. Nutritional factors: Calcium, phosphorus, protein, trace elements such as fluorine, magnesium, zinc, vitamin C, and vitamin D deficiency are closely related to osteoporosis. The main reason is the lack of calcium and phosphorus.

2. Lack of activity: Exercise, sunlight exposure, and gravity load are closely related to bone mass and the occurrence of osteoporosis. During exercise, neuroendocrine regulation provides sufficient mineral nutrition for bones, increasing systemic and local bone calcium content; exercise can also maintain a certain mechanical stimulation, stimulate the activity of bone cells, and increase bone formation; exercise can also slightly increase estrogen secretion in menopausal women.

3. Genetic factors: Bone loss is also related to genetic factors. Genetic factors are also an important cause of osteoporosis. For example, short people are more likely to suffer from osteoporosis than tall people; even if living conditions, physical conditions, environmental factors, gender and age are similar, the occurrence and degree of osteoporosis are different.

4. Endocrine: Contains estrogen, parathyroid hormone, calcitonin, active vitamin D, thyroxine, androgen, corticosteroids, growth hormone, etc. The first four hormones are particularly important, especially sex hormones, which play a decisive role, especially for women. For example, women who have had their ovaries removed or have premature menopause are prone to osteoporosis due to reduced or no estrogen secretion.

5. Failure factors: patients with fractures or bone diseases need long-term immobilization, long-term bed rest, muscle paralysis, which can cause osteoporosis. It is generally believed that when the body is in a static state for a long time, muscle activity decreases, bones lack muscle stimulation, osteoblasts decrease, normal bone metabolism is impaired, bone cells are relatively active, leading to bone calcium dissolution, increased urinary calcium excretion, and ultimately osteoporosis.