What are the causes of idiopathic osteoporosis?

What are the causes of idiopathic osteoporosis?

1. Idiopathic adolescent osteoporosis:

Idiopathic juvenile osteoporosis refers to a systemic bone metabolic disease that develops between the ages of 8 and 14 and has no clear cause. Since the first report of idiopathic juvenile osteoporosis by Schippers in Germany in 1938, more than 60 cases have been reported. Its typical manifestation is that adolescents and children begin with dull pain in the lower back, buttocks and feet, and gradually develop difficulty walking. Knee and ankle pain and lower limb fractures often occur. There is no gender difference in the incidence of idiopathic juvenile osteoporosis, and it is not related to family history and dietary structure. The whole body examination can be completely normal, or it can show thoracolumbar kyphosis, kyphosis, pigeon chest, and a ratio of head to pubic bone to heel less than 1.0. Short stature, long bone deformity, and lameness. Children with idiopathic osteoporosis mainly show bone loss, load-bearing fractures, and spinal collapse deformity under X-rays. Because the vertebral body is wedge-shaped, the intervertebral space widens asymmetrically, and sometimes bone sclerosis is manifested. The length and cortical width of long bones are generally normal.

2. Idiopathic adult osteoporosis:

Idiopathic adult osteoporosis is a systemic bone metabolic disease that occurs before menopause in adult women and before the age of 60 in men, including osteoporosis during pregnancy. Unlike idiopathic osteoporosis in growing adolescents, it has histological morphological characteristics such as decreased bone volume, decreased trabecular thickness, decreased bone surface activity, decreased bone mineralization, and decreased bone formation rate. Many patients present with hypercalcemia, which is generally considered to be caused by the inhibition of bone metabolism. The main clinical symptoms of the disease are similar to those of senile osteoporosis, that is, the symptoms related to spinal osteoporosis. The spine may show compression fractures, wedge-shaped vertebrae and fish vertebrae deformation, which can cause lumbar pain. Mild deformation only involves 1-2 vertebrae, and severe ones can involve the entire spine. Of course, in addition to spinal fractures, there are also many fractures of the ribs, pubis, and sciatic bones.